Cancer Immunotherapy “HLA-G an Important Neglected Immunosuppressive Molecule”
نویسنده
چکیده
Curigliano and Criscitiello, et al. [7] have addressed the molecular pathways of HLA-G. There are seven isoforms, four membrane bound (HLA-G1 to HLA-G-4); and three secreted isoforms (s HLA-G; HLA-G5 to HLA-G7). HLA-G5 is the soluble counterpart of HLA-G1; and most information known concerns the HLA-G1 molecule and its soluble counterpart HLA-G5. HLA-G induces tolerance and tumor Immunosuppression by inhibiting various immune-competent cells. The suppressive effect is caused by the binding of both soluble and membrane bound HLA-G to inhibitory receptors of effector immune cells, especially the Killer Cell Immunoglobulin-like Receptor (KIR) expressed on (NK) cells [7].
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